Longitudinal deterioration of white-matter integrity: Heterogeneity in the ageing population

Konstantinos Poulakis; Robert I. Reid; Scott A. Przybelski; David S. Knopman; Jonathan Graff-Radford; Val J. Lowe; Michelle M. Mielke; Mary M. Machulda; Clifford R. Jack; Ronald C. Petersen; Eric Westman; Prashanthi Vemuri

doi:10.1093/braincomms/fcaa238

Longitudinal deterioration of white-matter integrity: Heterogeneity in the ageing population

Konstantinos Poulakis, Robert I. Reid, Scott A. Przybelski, David S. Knopman, Jonathan Graff-Radford, Val J. Lowe, Michelle M. Mielke, Mary M. Machulda, Clifford R. Jack, Ronald C. Petersen, Eric Westman, Prashanthi Vemuri

Research output: Contribution to journal › Article › peer-review

Abstract

Deterioration in white-matter health plays a role in cognitive ageing. Our goal was to discern heterogeneity of white-matter tract vulnerability in ageing using longitudinal imaging data (two to five imaging and cognitive assessments per participant) from a population-based sample of 553 elderly participants (age ?60 years). We found that different clusters (healthy white matter, fast white-matter decliners and intermediate white-matter group) were heterogeneous in the spatial distribution of white-matter integrity, systemic health and cognitive trajectories. White-matter health of specific tracts (genu of corpus callosum, posterior corona radiata and anterior internal capsule) informed about cluster assignments. Not surprisingly, brain amyloidosis was not significantly different between clusters. Clusters had differential white-matter tract vulnerability to ageing (commissural fibres > association/brainstem fibres). Identification of vulnerable white-matter tracts is a valuable approach to assessing risk for cognitive decline.

Original language	English (US)
Article number	fcaa238
Journal	Brain Communications
Volume	3
Issue number	1
DOIs	https://doi.org/10.1093/braincomms/fcaa238
State	Published - 2021

Keywords

Cognitive decline
Longitudinal clustering
Resilience
White-matter microstructure

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Cellular and Molecular Neuroscience
Neurology

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10.1093/braincomms/fcaa238

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Poulakis, K., Reid, R. I., Przybelski, S. A., Knopman, D. S., Graff-Radford, J., Lowe, V. J., Mielke, M. M., Machulda, M. M., Jack, C. R., Petersen, R. C., Westman, E., & Vemuri, P. (2021). Longitudinal deterioration of white-matter integrity: Heterogeneity in the ageing population. Brain Communications, 3(1), Article fcaa238. https://doi.org/10.1093/braincomms/fcaa238

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abstract = "Deterioration in white-matter health plays a role in cognitive ageing. Our goal was to discern heterogeneity of white-matter tract vulnerability in ageing using longitudinal imaging data (two to five imaging and cognitive assessments per participant) from a population-based sample of 553 elderly participants (age ?60 years). We found that different clusters (healthy white matter, fast white-matter decliners and intermediate white-matter group) were heterogeneous in the spatial distribution of white-matter integrity, systemic health and cognitive trajectories. White-matter health of specific tracts (genu of corpus callosum, posterior corona radiata and anterior internal capsule) informed about cluster assignments. Not surprisingly, brain amyloidosis was not significantly different between clusters. Clusters had differential white-matter tract vulnerability to ageing (commissural fibres > association/brainstem fibres). Identification of vulnerable white-matter tracts is a valuable approach to assessing risk for cognitive decline.",

keywords = "Cognitive decline, Longitudinal clustering, Resilience, White-matter microstructure",

author = "Konstantinos Poulakis and Reid, {Robert I.} and Przybelski, {Scott A.} and Knopman, {David S.} and Jonathan Graff-Radford and Lowe, {Val J.} and Mielke, {Michelle M.} and Machulda, {Mary M.} and Jack, {Clifford R.} and Petersen, {Ronald C.} and Eric Westman and Prashanthi Vemuri",

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year = "2021",

doi = "10.1093/braincomms/fcaa238",

language = "English (US)",

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AU - Knopman, David S.

AU - Graff-Radford, Jonathan

AU - Lowe, Val J.

AU - Mielke, Michelle M.

AU - Machulda, Mary M.

AU - Jack, Clifford R.

AU - Petersen, Ronald C.

AU - Westman, Eric

AU - Vemuri, Prashanthi

PY - 2021

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AB - Deterioration in white-matter health plays a role in cognitive ageing. Our goal was to discern heterogeneity of white-matter tract vulnerability in ageing using longitudinal imaging data (two to five imaging and cognitive assessments per participant) from a population-based sample of 553 elderly participants (age ?60 years). We found that different clusters (healthy white matter, fast white-matter decliners and intermediate white-matter group) were heterogeneous in the spatial distribution of white-matter integrity, systemic health and cognitive trajectories. White-matter health of specific tracts (genu of corpus callosum, posterior corona radiata and anterior internal capsule) informed about cluster assignments. Not surprisingly, brain amyloidosis was not significantly different between clusters. Clusters had differential white-matter tract vulnerability to ageing (commissural fibres > association/brainstem fibres). Identification of vulnerable white-matter tracts is a valuable approach to assessing risk for cognitive decline.

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KW - Resilience

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Longitudinal deterioration of white-matter integrity: Heterogeneity in the ageing population

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Keywords

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