TY - JOUR
T1 - Long-term follow-up of acquired nonaccommodative esotropia in a population-based cohort
AU - Jacobs, Sarah M.
AU - Green-Simms, Amy
AU - Diehl, Nancy N.
AU - Mohney, Brian G.
N1 - Funding Information:
Supported in part by an unrestricted grant from Research to Prevent Blindness, Inc. , New York, New York, and by the Rochester Epidemiology Project (Grant R01-AR30582 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases ).
PY - 2011/6
Y1 - 2011/6
N2 - Purpose To describe the clinical characteristics and long-term outcomes of children diagnosed over a 30-year period with acquired nonaccommodative esotropia (ANAET). Design Retrospective chart review of a population-based cohort. Participants All pediatric (<19 years of age) residents of Olmsted County, Minnesota, who were diagnosed with ANAET from January 1, 1965, to December 31, 1994. Methods The medical records of all potential patients identified by the resources of the Rochester Epidemiology Project were reviewed. Main Outcome Measures Incidence, clinical characteristics, and long-term motor and sensory outcomes of children with ANAET. Results A total of 174 children were diagnosed during the 30-year period, yielding an incidence of 1 in 287 live births. The median age at diagnosis for the 174 patients was 4.0 years (range, 10 months to 18.2 years), and 61% (107) were male (P=0.009). Although 11% (8/75) of those queried were diplopic, none of the 174 was subsequently diagnosed with an intracranial lesion. During a mean follow-up of 10.9 years (range, 0 days to 37 years), 127 patients (73%) underwent strabismus surgery (mean, 1 surgery; range, 03 surgeries). Among the 127 patients who underwent surgery, the median final stereoacuity was 3000 seconds of arc, including 8 patients (6.3%) with ≥50 seconds of arc. Patients who were older (>44 months) at ANAET diagnosis (P = 0.005) and without amblyopia at their initial examination (P < 0.001) were more likely to achieve excellent final stereopsis. Conclusions In this population-based cohort, ANAET occurred in 1 in 287 children and was more prevalent among male children. Although diplopia was relatively common, none of the children were found to have an intracranial malignancy. Most patients achieved good motor and sensory outcomes, with the best results among those with a later onset of their deviation and no amblyopia. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article.
AB - Purpose To describe the clinical characteristics and long-term outcomes of children diagnosed over a 30-year period with acquired nonaccommodative esotropia (ANAET). Design Retrospective chart review of a population-based cohort. Participants All pediatric (<19 years of age) residents of Olmsted County, Minnesota, who were diagnosed with ANAET from January 1, 1965, to December 31, 1994. Methods The medical records of all potential patients identified by the resources of the Rochester Epidemiology Project were reviewed. Main Outcome Measures Incidence, clinical characteristics, and long-term motor and sensory outcomes of children with ANAET. Results A total of 174 children were diagnosed during the 30-year period, yielding an incidence of 1 in 287 live births. The median age at diagnosis for the 174 patients was 4.0 years (range, 10 months to 18.2 years), and 61% (107) were male (P=0.009). Although 11% (8/75) of those queried were diplopic, none of the 174 was subsequently diagnosed with an intracranial lesion. During a mean follow-up of 10.9 years (range, 0 days to 37 years), 127 patients (73%) underwent strabismus surgery (mean, 1 surgery; range, 03 surgeries). Among the 127 patients who underwent surgery, the median final stereoacuity was 3000 seconds of arc, including 8 patients (6.3%) with ≥50 seconds of arc. Patients who were older (>44 months) at ANAET diagnosis (P = 0.005) and without amblyopia at their initial examination (P < 0.001) were more likely to achieve excellent final stereopsis. Conclusions In this population-based cohort, ANAET occurred in 1 in 287 children and was more prevalent among male children. Although diplopia was relatively common, none of the children were found to have an intracranial malignancy. Most patients achieved good motor and sensory outcomes, with the best results among those with a later onset of their deviation and no amblyopia. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article.
UR - http://www.scopus.com/inward/record.url?scp=79958001845&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958001845&partnerID=8YFLogxK
U2 - 10.1016/j.ophtha.2010.10.032
DO - 10.1016/j.ophtha.2010.10.032
M3 - Article
C2 - 21276614
AN - SCOPUS:79958001845
SN - 0161-6420
VL - 118
SP - 1170
EP - 1174
JO - Ophthalmology
JF - Ophthalmology
IS - 6
ER -