Loin pain hematuria syndrome

Adeel S. Zubair, Hassan Salameh, Stephen B. Erickson, Mikel Prieto

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Loin pain hematuria syndrome (LPHS), first described in 1967, is a rare pain syndrome, which is not well understood. The syndrome is characterized by severe intermittent or persistent flank pain, either unilateral or bilateral, associated with gross or microscopic hematuria. LPHS is a diagnosis of exclusion as there still is not a consensus of validated diagnostic criteria, though several criteria have been proposed. The wide differential diagnosis would suggest a meticulous yet specific diagnostic work-up depending on the individual clinical features and natural history. Several mechanisms regarding the pathophysiology of LPHS have been proposed but without pinpointing the actual causative etiology, the treatment remains symptomatic. Treatment modalities for LPHS are diverse including simple analgesia, opioid analgesic and kidney autotransplantation. This review article summarizes the current understanding regarding the pathophysiology of LPHS along with the steps required for proper diagnosis and a discussion of the different therapeutic approaches for LPHS.

Original languageEnglish (US)
Pages (from-to)128-134
Number of pages7
JournalClinical Kidney Journal
Issue number1
StatePublished - Feb 1 2016


  • Autotransplant
  • Flank pain
  • Hematuria
  • Loin pain hematuria syndrome

ASJC Scopus subject areas

  • Nephrology
  • Transplantation


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