Localized scleroderma (morphea) and antibody to Borrelia burgdorferi

James M. Hoesly; Lester E. Mertz; R. K. Winkelmann

doi:10.1016/S0190-9622(87)70229-1

Localized scleroderma (morphea) and antibody to Borrelia burgdorferi

James M. Hoesly, Lester E. Mertz, R. K. Winkelmann

Rheumatology

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56 Scopus citations

Abstract

Enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA) were performed in 25 and 32 cases of morphea, respectively. The more sensitive and specific ELISA was positive in only 1 of 25 cases and the mean value was lower in cases of morphea than in controls. IFA showed minimally reactive titers in 6 (19%) of 32 cases. There were an additional six cases with borderline titers. These data indicate that there is no specific association between Borrelia burgdorferi infection and morphea but that patients with morphea tend to have circulating antibodies that are cross-reactive.

Original language	English (US)
Pages (from-to)	455-458
Number of pages	4
Journal	Journal of the American Academy of Dermatology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/S0190-9622(87)70229-1
State	Published - Jan 1 1987

ASJC Scopus subject areas

Dermatology

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title = "Localized scleroderma (morphea) and antibody to Borrelia burgdorferi",

abstract = "Enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA) were performed in 25 and 32 cases of morphea, respectively. The more sensitive and specific ELISA was positive in only 1 of 25 cases and the mean value was lower in cases of morphea than in controls. IFA showed minimally reactive titers in 6 (19%) of 32 cases. There were an additional six cases with borderline titers. These data indicate that there is no specific association between Borrelia burgdorferi infection and morphea but that patients with morphea tend to have circulating antibodies that are cross-reactive.",

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N2 - Enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA) were performed in 25 and 32 cases of morphea, respectively. The more sensitive and specific ELISA was positive in only 1 of 25 cases and the mean value was lower in cases of morphea than in controls. IFA showed minimally reactive titers in 6 (19%) of 32 cases. There were an additional six cases with borderline titers. These data indicate that there is no specific association between Borrelia burgdorferi infection and morphea but that patients with morphea tend to have circulating antibodies that are cross-reactive.

AB - Enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA) were performed in 25 and 32 cases of morphea, respectively. The more sensitive and specific ELISA was positive in only 1 of 25 cases and the mean value was lower in cases of morphea than in controls. IFA showed minimally reactive titers in 6 (19%) of 32 cases. There were an additional six cases with borderline titers. These data indicate that there is no specific association between Borrelia burgdorferi infection and morphea but that patients with morphea tend to have circulating antibodies that are cross-reactive.

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Localized scleroderma (morphea) and antibody to Borrelia burgdorferi

Abstract

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