Localization of the gene for X-linked spinal muscular atrophy

Kenneth H. Fischbeck, Victor Ionasescu, Albert W. Ritter, Rebecca Ionasescu, Kay Davies, Sarah Ball, Peter Bosch, Trude Burns, Irena Hausmanowa-Petrusewicz, Janina Borkowska, Steven P. Ringel, Lawrence Z. Stern

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


We used probes for DNA polymorphism on the X chromosome to study genetic linkage in seven families with X-linked adult-onset spinal muscular atrophy. We found significant linkage to the marker DXYS1 on the proximal X chromosome long arm and loose linkage or nonlinkage to markers elsewhere. Our analysis localizes the gene defect for this form of anterior horn cell disease.

Original languageEnglish (US)
Pages (from-to)1595-1598
Number of pages4
Issue number12
StatePublished - Dec 1986

ASJC Scopus subject areas

  • Clinical Neurology


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