TY - JOUR
T1 - Liver transplantation for acute liver failure
T2 - outcome analysis.
AU - Shakil, A. O.
AU - Dvorchik, I.
AU - Fung, J. J.
AU - Rakela, J.
PY - 1997
Y1 - 1997
N2 - Acute liver failure (ALF) remains a major cause of morbidity and mortality. Before the availability of liver transplantation only 20% of patients with ALF survived. The clinical dilemma relates to the prognostication of these patients, as early liver transplantation has been associated with better outcomes. The eligibility for liver transplantation must therefore be quickly established. The patient's age, aetiology of disease, interval between the onset of jaundice and encephalopathy, blood pH, prothrombin time, serum bilirubin and serum creatinine levels has been identified as useful prognostic markers. The degree of hepatocyte necrosis on liver biopsy and estimated hepatic volume by computed tomography may also be valuable predictors of survival; however, further studies are needed.
AB - Acute liver failure (ALF) remains a major cause of morbidity and mortality. Before the availability of liver transplantation only 20% of patients with ALF survived. The clinical dilemma relates to the prognostication of these patients, as early liver transplantation has been associated with better outcomes. The eligibility for liver transplantation must therefore be quickly established. The patient's age, aetiology of disease, interval between the onset of jaundice and encephalopathy, blood pH, prothrombin time, serum bilirubin and serum creatinine levels has been identified as useful prognostic markers. The degree of hepatocyte necrosis on liver biopsy and estimated hepatic volume by computed tomography may also be valuable predictors of survival; however, further studies are needed.
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U2 - 10.1111/j.1365-2893.1997.tb00170.x
DO - 10.1111/j.1365-2893.1997.tb00170.x
M3 - Review article
C2 - 9097288
AN - SCOPUS:0030634442
SN - 1352-0504
VL - 4 Suppl 1
SP - 107
EP - 110
JO - Journal of viral hepatitis
JF - Journal of viral hepatitis
ER -