Liver Transplant for Cholangiocarcinoma

Daniel Zamora-Valdes; Julie K. Heimbach

doi:10.1016/j.gtc.2018.01.002

Liver Transplant for Cholangiocarcinoma

Daniel Zamora-Valdes, Julie K. Heimbach

Transplant Surgery

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Liver transplant (LT) for perihilar cholangiocarcinoma (CCA) offers an opportunity for survival among patients with early-stage but anatomically unresectable disease. The 5-year survival rate after LT is 65% to 70%, higher among patients with primary sclerosing cholangitis, who are often diagnosed earlier, and lower among patients with de novo CCA. The results of LT for hilar CCA, along with recent limited data suggesting favorable survival among patients with very early intrahepatic CCA (ICC), have reignited interest in the subject. This article discusses LT following neoadjuvant therapy for CCA and the early data on LT alone for ICC.

Original language	English (US)
Pages (from-to)	267-280
Number of pages	14
Journal	Gastroenterology Clinics of North America
Volume	47
Issue number	2
DOIs	https://doi.org/10.1016/j.gtc.2018.01.002
State	Published - Jun 2018

Keywords

Hilar cholangiocarcinoma
Intrahepatic cholangiocarcinoma
Liver cancer
Liver transplantation
Neoadjuvant radiotherapy

ASJC Scopus subject areas

Gastroenterology

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10.1016/j.gtc.2018.01.002

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title = "Liver Transplant for Cholangiocarcinoma",

abstract = "Liver transplant (LT) for perihilar cholangiocarcinoma (CCA) offers an opportunity for survival among patients with early-stage but anatomically unresectable disease. The 5-year survival rate after LT is 65% to 70%, higher among patients with primary sclerosing cholangitis, who are often diagnosed earlier, and lower among patients with de novo CCA. The results of LT for hilar CCA, along with recent limited data suggesting favorable survival among patients with very early intrahepatic CCA (ICC), have reignited interest in the subject. This article discusses LT following neoadjuvant therapy for CCA and the early data on LT alone for ICC.",

keywords = "Hilar cholangiocarcinoma, Intrahepatic cholangiocarcinoma, Liver cancer, Liver transplantation, Neoadjuvant radiotherapy",

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T1 - Liver Transplant for Cholangiocarcinoma

AU - Zamora-Valdes, Daniel

AU - Heimbach, Julie K.

PY - 2018/6

Y1 - 2018/6

N2 - Liver transplant (LT) for perihilar cholangiocarcinoma (CCA) offers an opportunity for survival among patients with early-stage but anatomically unresectable disease. The 5-year survival rate after LT is 65% to 70%, higher among patients with primary sclerosing cholangitis, who are often diagnosed earlier, and lower among patients with de novo CCA. The results of LT for hilar CCA, along with recent limited data suggesting favorable survival among patients with very early intrahepatic CCA (ICC), have reignited interest in the subject. This article discusses LT following neoadjuvant therapy for CCA and the early data on LT alone for ICC.

AB - Liver transplant (LT) for perihilar cholangiocarcinoma (CCA) offers an opportunity for survival among patients with early-stage but anatomically unresectable disease. The 5-year survival rate after LT is 65% to 70%, higher among patients with primary sclerosing cholangitis, who are often diagnosed earlier, and lower among patients with de novo CCA. The results of LT for hilar CCA, along with recent limited data suggesting favorable survival among patients with very early intrahepatic CCA (ICC), have reignited interest in the subject. This article discusses LT following neoadjuvant therapy for CCA and the early data on LT alone for ICC.

KW - Hilar cholangiocarcinoma

KW - Intrahepatic cholangiocarcinoma

KW - Liver cancer

KW - Liver transplantation

KW - Neoadjuvant radiotherapy

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U2 - 10.1016/j.gtc.2018.01.002

DO - 10.1016/j.gtc.2018.01.002

M3 - Review article

AN - SCOPUS:85046794456

SN - 0889-8553

VL - 47

SP - 267

EP - 280

JO - Gastroenterology Clinics of North America

JF - Gastroenterology Clinics of North America

IS - 2

ER -

Liver Transplant for Cholangiocarcinoma

Abstract

Keywords

ASJC Scopus subject areas

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