Liver aquaporins: significance in canalicular and ductal bile formation.

Raúl A. Marinelli, Sergio A. Gradilone, Flavia I. Carreras, Giuseppe Calamita, Guillermo L. Lehmann

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Abstract Bile is primarily secreted in hepatocytes (i.e. the canalicular bile) and subsequently delivered to the intrahepatic bile ducts, where is modified by cholangiocytes (i.e. the ductal bile). Bile formation is the result of the coordinated interactions of membrane-transport systems that generate the vectorial movement of solutes and osmotically driven water molecules. Hepatocytes and cholangiocytes express aquaporins, specialized membrane channel proteins that facilitate the osmotic transport of water. In this review, we provide a summary of what is known on liver AQPs and their significance in canalicular and ductal bile formation under normal and pathological conditions.

Original languageEnglish (US)
Pages (from-to)130-136
Number of pages7
JournalAnnals of hepatology : official journal of the Mexican Association of Hepatology
Issue number4
StatePublished - 2004

ASJC Scopus subject areas

  • Hepatology


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