TY - JOUR
T1 - Lipoprotein-based drug delivery
AU - Busatto, Sara
AU - Walker, Sierra A.
AU - Grayson, Whisper
AU - Pham, Anthony
AU - Tian, Ming
AU - Nesto, Nicole
AU - Barklund, Jacqueline
AU - Wolfram, Joy
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/1
Y1 - 2020/1
N2 - Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound lipoprotein lipase. The stability, biocompatibility, and selective transport of LPs make them promising delivery vehicles for various therapeutic and imaging agents. This review discusses isolation, manufacturing, and drug loading techniques used for LP-based drug delivery, as well as recent applications for diagnosis and treatment of cancer, atherosclerosis, and other life-threatening diseases.
AB - Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound lipoprotein lipase. The stability, biocompatibility, and selective transport of LPs make them promising delivery vehicles for various therapeutic and imaging agents. This review discusses isolation, manufacturing, and drug loading techniques used for LP-based drug delivery, as well as recent applications for diagnosis and treatment of cancer, atherosclerosis, and other life-threatening diseases.
KW - Biocompatible nanoparticles
KW - Chemotherapy
KW - Chylomicrons
KW - Drug delivery
KW - High-density lipoproteins
KW - Low-density lipoproteins
KW - Lymphatic transport
KW - Purification
KW - Synthetic lipoproteins
KW - Very low-density lipoproteins
UR - http://www.scopus.com/inward/record.url?scp=85089725481&partnerID=8YFLogxK
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U2 - 10.1016/j.addr.2020.08.003
DO - 10.1016/j.addr.2020.08.003
M3 - Review article
C2 - 32791075
AN - SCOPUS:85089725481
SN - 0169-409X
VL - 159
SP - 377
EP - 390
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -