Lipodermatosclerosis: Review of cases evaluated at Mayo Clinic

Alison J. Bruce, Daniel D. Bennett, Christine M. Lohse, Thom W. Rooke, Mark D.P. Davis

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Background: Lipodermatosclerosis describes bound-down, sclerotic skin involving the lower extremities. Objective: Our purpose was to describe the demographic and clinical features of patients with lipodermatosclerosis. Methods: This was a retrospective study of patients presenting to Mayo Clinic between 1976 and 1998 with a diagnosis of lipodermatosclerosis. Results: Of 97 patients, 84 (87%) were women. Mean age was 62 years (range, 25-88 years). Mean body mass index was 34.3 (range, 17.8-71.5). Clinical signs were bilateral involvement in 44 patients (45%), induration localized to a discrete plaque in 49 (51%), erythema in 69 (71%), hyperpigmentation in 57 (59%), ulceration in 13 (13%), concomitant edema in 69 (71%), and varicosities in 55 (57%). Vascular studies performed on 72 patients showed abnormalities in 49: deep venous incompetence in 33 (67%), calf muscle pump abnormality in 19 (39%), abnormal pulsatility in 10 (20%), and obstruction in 1 (2%). Conclusion: Lipodermatosclerosis was associated with female sex, middle age, high body mass index, and venous abnormalities.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalJournal of the American Academy of Dermatology
Issue number2
StatePublished - 2002

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Lipodermatosclerosis: Review of cases evaluated at Mayo Clinic'. Together they form a unique fingerprint.

Cite this