Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

Pamela Thompson; Vani Lakshminarayanan; Nitin T. Supekar; Judy M. Bradley; Peter A. Cohen; Margreet A. Wolfert; Sandra J. Gendler; Geert Jan Boons

doi:10.1039/c5cc02199e

Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

Pamela Thompson, Vani Lakshminarayanan, Nitin T. Supekar, Judy M. Bradley, Peter A. Cohen, Margreet A. Wolfert, Sandra J. Gendler, Geert Jan Boons

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T-cells primed by such a vaccine candidate could be restimulated by tumor-associated MUC1.

Original language	English (US)
Pages (from-to)	10214-10217
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	50
DOIs	https://doi.org/10.1039/c5cc02199e
State	Published - May 28 2015

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/c5cc02199e

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title = "Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide",

abstract = "A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T-cells primed by such a vaccine candidate could be restimulated by tumor-associated MUC1.",

author = "Pamela Thompson and Vani Lakshminarayanan and Supekar, {Nitin T.} and Bradley, {Judy M.} and Cohen, {Peter A.} and Wolfert, {Margreet A.} and Gendler, {Sandra J.} and Boons, {Geert Jan}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2015",

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doi = "10.1039/c5cc02199e",

language = "English (US)",

volume = "51",

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TY - JOUR

T1 - Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

AU - Thompson, Pamela

AU - Lakshminarayanan, Vani

AU - Supekar, Nitin T.

AU - Bradley, Judy M.

AU - Cohen, Peter A.

AU - Wolfert, Margreet A.

AU - Gendler, Sandra J.

AU - Boons, Geert Jan

PY - 2015/5/28

Y1 - 2015/5/28

N2 - A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T-cells primed by such a vaccine candidate could be restimulated by tumor-associated MUC1.

AB - A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T-cells primed by such a vaccine candidate could be restimulated by tumor-associated MUC1.

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U2 - 10.1039/c5cc02199e

DO - 10.1039/c5cc02199e

M3 - Article

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SP - 10214

EP - 10217

JO - Chemical Communications

JF - Chemical Communications

IS - 50

ER -

Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

Abstract

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