Limitin: An interferon-like cytokine that preferentially influences B- lymphocyte precursors

Kenji Oritani; Kay L. Medina; Yoshiaki Tomiyama; Jun Ishikawa; Yu Okajima; Megumu Ogawa; Takahumi Yokota; Keisuke Aoyama; Isao Takahashi; Paul W. Kincade; Yuji Matsuzawa

doi:10.1038/76233

Limitin: An interferon-like cytokine that preferentially influences B- lymphocyte precursors

Kenji Oritani, Kay L. Medina, Yoshiaki Tomiyama, Jun Ishikawa, Yu Okajima, Megumu Ogawa, Takahumi Yokota, Keisuke Aoyama, Isao Takahashi, Paul W. Kincade, Yuji Matsuzawa

Immunology

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho-hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon α/β receptors and induces interferon regulatory factor- 1, it may represent a previously unknown type 1 interferon prototype. However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons.

Original language	English (US)
Pages (from-to)	659-666
Number of pages	8
Journal	Nature Medicine
Volume	6
Issue number	6
DOIs	https://doi.org/10.1038/76233
State	Published - Jun 2000

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1038/76233

Cite this

@article{4526cd6ad1c94269abe23391c91d0cc8,

title = "Limitin: An interferon-like cytokine that preferentially influences B- lymphocyte precursors",

abstract = "We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho-hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon α/β receptors and induces interferon regulatory factor- 1, it may represent a previously unknown type 1 interferon prototype. However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons.",

author = "Kenji Oritani and Medina, {Kay L.} and Yoshiaki Tomiyama and Jun Ishikawa and Yu Okajima and Megumu Ogawa and Takahumi Yokota and Keisuke Aoyama and Isao Takahashi and Kincade, {Paul W.} and Yuji Matsuzawa",

note = "Funding Information: Acknowledgments This work was supported in part by grants from the Yamanouchi Foundation for Research on Metabolic Disorders, the Kowa Life Science Foundation, the Ministry of Education, Science and Culture of Japan and the Japan Society for the Promotion of Science as well as grants AI-33085 and AI-20069 from the National Institutes of Health.",

year = "2000",

month = jun,

doi = "10.1038/76233",

language = "English (US)",

volume = "6",

pages = "659--666",

journal = "Nature Medicine",

issn = "1078-8956",

publisher = "Nature Publishing Group",

number = "6",

}

TY - JOUR

T1 - Limitin

T2 - An interferon-like cytokine that preferentially influences B- lymphocyte precursors

AU - Oritani, Kenji

AU - Medina, Kay L.

AU - Tomiyama, Yoshiaki

AU - Ishikawa, Jun

AU - Okajima, Yu

AU - Ogawa, Megumu

AU - Yokota, Takahumi

AU - Aoyama, Keisuke

AU - Takahashi, Isao

AU - Kincade, Paul W.

AU - Matsuzawa, Yuji

N1 - Funding Information: Acknowledgments This work was supported in part by grants from the Yamanouchi Foundation for Research on Metabolic Disorders, the Kowa Life Science Foundation, the Ministry of Education, Science and Culture of Japan and the Japan Society for the Promotion of Science as well as grants AI-33085 and AI-20069 from the National Institutes of Health.

PY - 2000/6

Y1 - 2000/6

N2 - We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho-hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon α/β receptors and induces interferon regulatory factor- 1, it may represent a previously unknown type 1 interferon prototype. However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons.

AB - We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho-hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon α/β receptors and induces interferon regulatory factor- 1, it may represent a previously unknown type 1 interferon prototype. However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons.

UR - http://www.scopus.com/inward/record.url?scp=0034089107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034089107&partnerID=8YFLogxK

U2 - 10.1038/76233

DO - 10.1038/76233

M3 - Article

C2 - 10835682

AN - SCOPUS:0034089107

SN - 1078-8956

VL - 6

SP - 659

EP - 666

JO - Nature Medicine

JF - Nature Medicine

IS - 6

ER -

Limitin: An interferon-like cytokine that preferentially influences B- lymphocyte precursors

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this