TY - JOUR
T1 - Lifestyle and anthropometric risk factors for prostate cancer in a cohort of Iowa men
AU - Putnam, Shannon D.
AU - Cerhan, James R.
AU - Parker, Alexander S.
AU - Bianchi, Gregory D.
AU - Wallace, Robert B.
AU - Cantor, Kenneth P.
AU - Lynch, Charles F.
N1 - Funding Information:
We thank Diana Wagner and Carla Van Hoesen, State Health Registry of Iowa, for linkage of data files, and Mary Jo Janisch, Mayo Clinic, for assistance in preparing the manuscript. This research was supported by the grants R21 CA/ES69838 and P30 ES05605 and the contracts N01-CP-51026 and N01-CP-85614. Dr. Cerhan was supported in part by a National Cancer Institute Preventive Oncology Academic Award (K07 CA64220).
PY - 2000/8
Y1 - 2000/8
N2 - PURPOSE: Several lines of evidence suggest that prostate cancer has a hormonal etiology. We evaluated factors known to modulate the endocrine system, including alcohol and tobacco use, physical activity, and obesity as risk factors for prostate cancer. METHODS: Cancer-free controls (n = 1572) who participated in a population-based case-control study from 1986-1989 (81% response rate) were followed through 1995 for cancer incidence by linkage to the Iowa Cancer Registry; 101 incident prostate cancers were identified. RESULTS: Compared with non-users of alcohol, men who consumed < 22 grams alcohol per week (relative risk [RR] = 1.1; 95% Confidence Interval [CI] 0.6- 2.1), 22-96 grams alcohol per week (RR = 2.6; 95% CI 1.4-4.6) and > 96 grams alcohol per week (RR = 3.1; 95% CI 1.5-6.3) were at increased risk of prostate cancer after adjustment for age, family history of prostate cancer, body mass index, total energy, and intake of carbohydrate, linoleic acid, lycopene, retinol, and red meat (p for trend < 0.0001). The respective RRs were similar when assessing type of alcohol consumed (beer, wine or liquor) or when well-differentiated, localized tumors were excluded. Body mass index was only weakly and positively associated with prostate cancer after adjustment for age (p for trend = 0.3), but this association strengthened after multivariate adjustment (p for trend = 0.08) and exclusion of well- differentiated, localized tumors (p for trend = 0.03). For the latter tumors, men with a BMI of 24.1-26.6 kg/m2 (RR = 1.5; 95% CI 0.7-3.0 and > 26.6 kg/m2 (RR = 2.1; 95% CI 1.1-4.3) were at elevated risk compared to men with a BMI < 24.1 kg/m2. Tobacco use (cigarettes, cigar/pipe, chewing tobacco and snuff use), height, weight, and both leisure and occupational physical activity were not associated with risk of prostate cancer in this cohort. CONCLUSIONS: These data suggest that in white men obesity is a risk factor for more clinically significant prostate cancer and confirm limited previous reports showing that alcohol consumption is positively associated with prostate cancer and that this risk is not limited to any specific type of alcohol.
AB - PURPOSE: Several lines of evidence suggest that prostate cancer has a hormonal etiology. We evaluated factors known to modulate the endocrine system, including alcohol and tobacco use, physical activity, and obesity as risk factors for prostate cancer. METHODS: Cancer-free controls (n = 1572) who participated in a population-based case-control study from 1986-1989 (81% response rate) were followed through 1995 for cancer incidence by linkage to the Iowa Cancer Registry; 101 incident prostate cancers were identified. RESULTS: Compared with non-users of alcohol, men who consumed < 22 grams alcohol per week (relative risk [RR] = 1.1; 95% Confidence Interval [CI] 0.6- 2.1), 22-96 grams alcohol per week (RR = 2.6; 95% CI 1.4-4.6) and > 96 grams alcohol per week (RR = 3.1; 95% CI 1.5-6.3) were at increased risk of prostate cancer after adjustment for age, family history of prostate cancer, body mass index, total energy, and intake of carbohydrate, linoleic acid, lycopene, retinol, and red meat (p for trend < 0.0001). The respective RRs were similar when assessing type of alcohol consumed (beer, wine or liquor) or when well-differentiated, localized tumors were excluded. Body mass index was only weakly and positively associated with prostate cancer after adjustment for age (p for trend = 0.3), but this association strengthened after multivariate adjustment (p for trend = 0.08) and exclusion of well- differentiated, localized tumors (p for trend = 0.03). For the latter tumors, men with a BMI of 24.1-26.6 kg/m2 (RR = 1.5; 95% CI 0.7-3.0 and > 26.6 kg/m2 (RR = 2.1; 95% CI 1.1-4.3) were at elevated risk compared to men with a BMI < 24.1 kg/m2. Tobacco use (cigarettes, cigar/pipe, chewing tobacco and snuff use), height, weight, and both leisure and occupational physical activity were not associated with risk of prostate cancer in this cohort. CONCLUSIONS: These data suggest that in white men obesity is a risk factor for more clinically significant prostate cancer and confirm limited previous reports showing that alcohol consumption is positively associated with prostate cancer and that this risk is not limited to any specific type of alcohol.
KW - Obesity
KW - Physical Activity
KW - Prostate Cancer
KW - Smoking
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U2 - 10.1016/S1047-2797(00)00057-0
DO - 10.1016/S1047-2797(00)00057-0
M3 - Article
C2 - 10964002
AN - SCOPUS:0033841952
SN - 1047-2797
VL - 10
SP - 361
EP - 369
JO - Annals of Epidemiology
JF - Annals of Epidemiology
IS - 6
ER -