Lichen planus

Aaron R. Mangold, Mark R. Pittelkow

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Lichen planus (LP) is the prototypical lichenoid tissue reaction (LTR) that affects approximately 1 % of the population worldwide. Classic LP is characterized by violaceous, flattopped, polygonal papules, which favor the flexor aspects of the body. LP can affect any ectodermally derived tissues (skin, hair, nail, mucous membranes, esophagus) and therefore a complete physical examination and multidisciplinary approach is often needed. Histologically, LP is characterized by basal keratinocyte damage with a brisk LTR. While there is a clear genetic association with LP, the pathogenesis remains unknown. Antigen presenting cells and T-lymphocytes play a key role in antigen recognition, lymphocyte activation, keratinocyte apoptosis, and disease resolution. Numerous therapeutic modalities have been utilitzed in LP. We recommend the usage of anti-inflammatory agents, which specifically target T-lymphocytes. Future, novel therapeutic targeting of cytotoxic T-lymphocytes make mechanistic sense; although, future studies are needed for both clinical efficacy and safety.

Original languageEnglish (US)
Title of host publicationClinical and Basic Immunodermatology
Subtitle of host publicationSecond Edition
PublisherSpringer International Publishing
Number of pages26
ISBN (Electronic)9783319297859
ISBN (Print)9783319297835
StatePublished - Apr 24 2017


  • Cutaneous disease
  • Esophagus
  • Hair
  • Hepatitis C
  • LP
  • Lichen Planus
  • Morphology
  • Mucous membranes
  • Nail
  • Pathogenesis
  • Skin
  • Skin disease
  • Tree moss

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology


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