Levosimendan in Cardiac Surgery: Evaluating the Evidence

Shaji A. Faisal, David A. Apatov, Harish Ramakrishna, Menachem M. Weiner

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Levosimendan, a calcium-sensitizing and Adenosine triphosphate-sensitive potassium channel opening inodilator, has the potential to improve cardiac function without increasing oxygen consumption. The evidence supporting the use of levosimendan in the cardiac surgical perioperative period is not well-established. Recently, large-scale randomized controlled trials studying the utility of levosimendan in cardiac surgery have been conducted. This review examines the physiological and pharmacologic properties of levosimendan and evaluates the literature regarding the use of levosimendan in patients undergoing cardiac surgery.

Original languageEnglish (US)
Pages (from-to)1146-1158
Number of pages13
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number4
StatePublished - Apr 2019


  • cardiac surgery
  • inotropes
  • levosimendan
  • low cardiac output syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine


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