Levodopa-nonresponsive lewy body parkinsonism: Clinicopathologic study of two cases

Margery H. Mark, J. I. Sage, D. W. Dickson, K. O. Schwarz, R. C. Duvoisin

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


We report two patients with a primarily akinetic form of parkinsonism who were nonresponsive to treatment with levodopa. At autopsy, both patients had many Lewy bodies in brainstem and diencephalic nuclei, with sparse Lewy bodies in association cortices and more numerous Lewy bodies in the limbic cortices, consistent with the transitional form of Lewy body disease. These cases emphasize that (1) Lewy body Parkinson's disease cannot be excluded on the basis of atypical presentation or levodopa nonresponsiveness, and (2) the clinicopathologic spectrum of Lewy body disease is varied.

Original languageEnglish (US)
Pages (from-to)1323-1327
Number of pages5
Issue number7
StatePublished - Jul 1992

ASJC Scopus subject areas

  • Clinical Neurology


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