M. C. Patterson

Research output: Chapter in Book/Report/Conference proceedingChapter


The term leukoencephalopathy embraces essentially any disorder involving the white matter of the central nervous system. Such disorders may result from mutations in genes encoding the components of myelin or associated molecules, or may be acquired manifestations of vascular, inflammatory, infectious, traumatic, toxic, nutritional, or neoplastic disease. Leukoencephalopathies, in general, produce symptoms and signs related to disruption of fiber tracts within the nervous system, particularly spasticity, visual impairment related to interruption of the visual pathways and, later in the illness, cognitive deficits related to disconnection of various cortical and subcortical regions.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Number of pages2
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
StatePublished - Jan 1 2014


  • Infectious
  • Inflammatory
  • Leukodystrophy
  • Leukoencephalopathy
  • Multiple sclerosis
  • Myelin
  • Neoplastic
  • Nutritional
  • Toxic
  • Traumatic
  • Vascular
  • White matter

ASJC Scopus subject areas

  • Medicine(all)


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