Lesions of unknown histogenesis: Langerhans cell histiocytosis and Ewing sarcoma

M. J. Kransdorf, S. E. Smith

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Langerhans cell histiocytosis (LCH) and Ewing sarcoma represent lesions of unknown histogenesis. Both lesions typically affect children and adolescents. Imaging features frequently suggest the diagnosis, and both lesions may demonstrate aggressive characteristics. LCH shows a broader spectrum of imaging findings, depending on lesion activity and location, which are reviewed in this article. Ewing sarcoma typically reveals both osseous and soft tissue involvement, although direct continuity of the components is often not apparent. Knowledge of the spectrum of clinical and radiologic features facilitates early diagnosis and can be used to evaluate the effects of therapy.

Original languageEnglish (US)
Pages (from-to)113-125
Number of pages13
JournalSeminars in Musculoskeletal Radiology
Issue number1
StatePublished - 2000


  • Bone
  • Ewing sarcoma
  • Langerhans cell histiocytosis
  • Neoplasm

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Radiology Nuclear Medicine and imaging


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