Leptomeningeal metastases of solid cancer

Emilie Le Rhun, Evanthia Galanis

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Purpose of review To review recent original data on leptomeningeal metastases in patients with solid cancer. Recent findings Lung and breast cancer as well as melanoma remain the most common primaries. Advanced cytological methods and targeted sequencing for candidate tumor-specific mutations may improve the sensitivity of cerebrospinal fluid diagnostics in leptomeningeal metastases. Targeted treatments like epidermal growth factor receptor tyrosine kinase inhibitors for non-small cell lung cancer, anti-human epidermal growth factor receptor-2 treatments for breast cancer or B-rapidly accelerated fibrosarcoma-targeted or immunotherapy for melanoma have an emerging role in the management of this condition. Summary Novel diagnostic approaches and the introduction of targeted agents may improve the clinical management of patients with leptomeningeal metastases from solid cancers.

Original languageEnglish (US)
Pages (from-to)797-805
Number of pages9
JournalCurrent opinion in neurology
Issue number6
StatePublished - Nov 13 2016


  • Brain metastases
  • Carcinomatous meningitis
  • Cerebrospinal fluid
  • Leptomeningeal metastasis
  • Neoplastic meningitis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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