Lentiviral vectors

Nils Loewen; Eric M. Poeschla

doi:10.1007/10_007

Lentiviral vectors

Nils Loewen, Eric M. Poeschla

Molecular Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

30 Scopus citations

Abstract

We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with integrated transgenes. Safety issues, including insertional mutagenesis and replication-competent retroviruses, are discussed. Innate cellular defenses against retroviruses and their implications for human gene therapy with different lentiviral vectors are also addressed.

Original language	English (US)
Title of host publication	Gene Therapy and Gene Delivery Systems
Pages	169-191
Number of pages	23
DOIs	https://doi.org/10.1007/10_007
State	Published - Nov 8 2005

Publication series

Name	Advances in Biochemical Engineering/Biotechnology
Volume	99
ISSN (Print)	0724-6145

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

Access to Document

10.1007/10_007

Cite this

@inbook{3d9fda40e08d4915850ddda7e6534278,

title = "Lentiviral vectors",

abstract = "We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with integrated transgenes. Safety issues, including insertional mutagenesis and replication-competent retroviruses, are discussed. Innate cellular defenses against retroviruses and their implications for human gene therapy with different lentiviral vectors are also addressed.",

author = "Nils Loewen and Poeschla, {Eric M.}",

year = "2005",

month = nov,

day = "8",

doi = "10.1007/10_007",

language = "English (US)",

isbn = "3540284044",

series = "Advances in Biochemical Engineering/Biotechnology",

pages = "169--191",

booktitle = "Gene Therapy and Gene Delivery Systems",

}

TY - CHAP

T1 - Lentiviral vectors

AU - Loewen, Nils

AU - Poeschla, Eric M.

PY - 2005/11/8

Y1 - 2005/11/8

N2 - We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with integrated transgenes. Safety issues, including insertional mutagenesis and replication-competent retroviruses, are discussed. Innate cellular defenses against retroviruses and their implications for human gene therapy with different lentiviral vectors are also addressed.

AB - We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with integrated transgenes. Safety issues, including insertional mutagenesis and replication-competent retroviruses, are discussed. Innate cellular defenses against retroviruses and their implications for human gene therapy with different lentiviral vectors are also addressed.

UR - http://www.scopus.com/inward/record.url?scp=33745064910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745064910&partnerID=8YFLogxK

U2 - 10.1007/10_007

DO - 10.1007/10_007

M3 - Chapter

C2 - 16568892

AN - SCOPUS:33745064910

SN - 3540284044

SN - 9783540284048

T3 - Advances in Biochemical Engineering/Biotechnology

SP - 169

EP - 191

BT - Gene Therapy and Gene Delivery Systems

ER -

Lentiviral vectors

Abstract

Publication series

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this