Left atrial appendage occlusion: Opportunities and challenges

David R. Holmes, Dhanunjaya R. Lakkireddy, Richard P. Whitlock, Ron Waksman, Michael J. Mack

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


Stroke prevention in patients with atrial fibrillation is a growing clinical dilemma as the incidence of the arrhythmia increases and risk profiles worsen. Strategies in patients with nonvalvular atrial fibrillation have included anticoagulation with a variety of drugs. Knowledge that stroke in this setting typically results from thrombus in the left atrial appendage has led to the development of mechanical approaches, both catheter-based and surgical, to occlude that structure. Such a device, if it were safe and effective, might avoid the need for anticoagulation and prevent stroke in the large number of patients who are currently not treated with anticoagulants. Regulatory approval has been difficult due to trial design challenges, balance of the risk-benefit ratio, specific patient populations studied, selection of treatment in the control group, and specific endpoints and statistical analyses selected. Accumulating data from randomized trials and registries with longer-term follow-up continues to support a role for left atrial appendage exclusion from the central circulation as an alternative to anticoagulation in carefully-selected patient populations.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalJournal of the American College of Cardiology
Issue number4
StatePublished - Feb 4 2014


  • Watchman device
  • left atrial appendage occlusion
  • nonvalvular atrial fibrillation
  • stroke prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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