Left atrial appendage occlusion

David R. Holmes, Kasper Korsholm, Josep Rodés-Cabau, Jacqueline Saw, Sergio Berti, Mohamad A. Alkhouli

Research output: Contribution to journalArticlepeer-review


Prevention of stroke represents a goal of primary importance in health systems due to its associated morbidity and mortality. As several patient groups with increased stroke rates have been identified, multiple approaches have been developed and implemented: oral anticoagulation (OAC) for patients with atrial fibrillation, surgical and percutaneous revascularisation in patients with carotid disease, device closure for patients with patent foramen ovale, and now, left atrial appendage occlusion (LAAO) for selected patients with non-valvular atrial fibrillation (NVAF). The latter group of patients are the focus of this review which evaluates the pathophysiology, selection of patients, procedural performance, outcomes of treatment both during and post-procedure, adjunctive therapy, complications, and longer-term outcomes.

Original languageEnglish (US)
Pages (from-to)E1038-E1065
Issue number13
StatePublished - Feb 2023


  • anticoagulation
  • atrial fibrillation
  • ischaemic stroke
  • left atrial appendage occlusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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