Laser-induced stress transients: Applications for molecular delivery

Thomas I. Flotte, Shun Lee, Hong Zhang, Daniel McAuliffe, Tina Douki, Apostolos Doukas

Research output: Contribution to journalConference articlepeer-review

13 Scopus citations


Lasers can be used to enhance the delivery of a number of molecules. Other investigators have demonstrated local release of molecules from liposomes following laser irradiation, microbeam disruption of the cell membrane to increase cell transport, microbeam ablation of the zona pellucida surrounding the ovum to increase the chances of fertilization, and increased transcutaneous transport following ablation of the stratum corneum. Our experiments have shown that laser-induced stress transients can be utilized as a vector for intracellular delivery of molecules that may or may not normally cross the cell membrane. These two conditions have been tested with Photofrin and DNA. This technology may have applications in cell and molecular biology, cancer therapy, gene therapy, and others.

Original languageEnglish (US)
Pages (from-to)202-207
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - May 22 1995
EventLaser-Tissue Interaction VI 1995 - San Jose, United States
Duration: Feb 1 1995Feb 8 1995


  • Cancer therapy
  • Gene therapy
  • Genetic vectors
  • Laser
  • Pressure

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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