Langerhan’s cell sarcoma: Two case reports

Tasneem A. Kaleem, Michael H. Schild, Daniel Miller, Asit Jha, Cherise Cortese, Steven Attia, Robert C. Miller

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Langerhan’s cell sarcoma (LCS) is a rare neoplasm with a poor prognosis. To our knowledge, only sixty-six cases have been published. We discuss two patients who presented very differently with LCS, as well as a recently published review of all sixty-six cases. Our first case had a complicated history of metastatic, high-grade myxofibrosarcomas and presented with a single skin lesion of LCS which was treated with resection to a positive margin and adjuvant radiotherapy. The LCS recurred locoregionally and was again resected. The patient is alive two years after initial diagnosis. The second case presented with bone marrow and splenic involvement, leukocytosis, and thrombocytopenia. This patient had an excellent response to etoposide, prednisone, oncovorin, cyclophosphamide, and adriamycin, with normalization of the complete blood count, negative bone marrow biopsy at follow up, and splenectomy without viable neoplasm. This patient is alive without signs of disease at 16 months after initial diagnosis.

Original languageEnglish (US)
Article number6140
Pages (from-to)17-19
Number of pages3
JournalRare Tumors
Issue number1
StatePublished - 2016


  • Cancer
  • Langerhan’s
  • Medicine
  • Oncology
  • Rare
  • Sarcoma
  • Tumor

ASJC Scopus subject areas

  • Histology
  • Oncology


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