L-methionine decreases dendritic spine density in mouse frontal cortex

Patricia Tueting, John M. Davis, Marin Veldic, Fabio Pibiri, Bashkim Kadriu, Alessandro Guidotti, Erminio Costa

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Schizophrenia postmortem brain is characterized by γ aminobutyric acid downregulation and by decreased dendritic spine density in frontal cortex. Protracted L-methionine treatment exacerbates schizophrenia symptoms, and our earlier work (Tremolizzo et al. and Dong et al.) has shown that L-methionine decreases reelin and GAD67 transcription in mice which is prevented by co-administration of valproate. In this study, we observed a decrease in spine density following L-methionine treatment, which was prevented by co-administration of valproate. Together with our earlier findings conducted under the same experimental conditions, we suggest that downregulation of spine density in L-methionine-treated mice may be because of the decreased expression of reelin and that valproate may prevent spine downregulation by inhibiting the methylation induced decrease in reelin.

Original languageEnglish (US)
Pages (from-to)543-548
Number of pages6
Issue number8
StatePublished - Jun 2010


  • Dendritic spines
  • Frontal cortex
  • GAD67
  • L-methionine
  • Methylation
  • Reelin
  • Schizophrenia
  • Valproate

ASJC Scopus subject areas

  • General Neuroscience


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