KLRG1+ memory CD8 T cells combine properties of short-lived effectors and long-lived memory

Kristin R. Renkema, Matthew A. Huggins, Henrique Borges Da Silva, Todd P. Knutson, Christy M. Henzler, Sara E. Hamilton

Research output: Contribution to journalArticlepeer-review


CD8 effector T cells with a CD127hi KLRG12 phenotype are considered precursors to the long-lived memory pool, whereas KLRG1+CD127low cells are viewed as short-lived effectors. Nevertheless, we and others have shown that a KLRG1+CD127low population persists into the memory phase and that these T cells (termed long-lived effector cells [LLEC]) display robust protective function during acute rechallenge with bacteria or viruses. Whether these T cells represent a true memory population or are instead a remnant effector cell population that failed to undergo initial contraction has remained unclear. In this study, we show that LLEC from mice express a distinct phenotypic and transcriptional signature that shares characteristics of both early effectors and long-lived memory cells. We also find that in contrast to KLRG1+ effector cells, LLEC undergo homeostatic proliferation and are not critically dependent on IL-15 for their maintenance. Furthermore, we find that LLEC are predominantly derived from KLRG1+ effector cells when isolated at day 12 of the response. Our work challenges the concept that the KLRG1+CD127low population is dominated by short-lived cells and shows that KLRG1 downregulation is not a prerequisite to become a long-lived protective memory T cell.

Original languageEnglish (US)
Pages (from-to)1059-1069
Number of pages11
JournalJournal of Immunology
Issue number4
StatePublished - Aug 15 2020

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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