Kidney transplantation: Mechanisms of rejection and acceptance

Lynn D. Cornell, R. Neal Smith, Robert B. Colvin

Research output: Chapter in Book/Report/Conference proceedingChapter

143 Scopus citations


We describe the molecular and cellular mechanisms believed to be responsible for the rejection of renal allografts, including acute T cell-mediated rejection, acute antibody-mediated (humoral) rejection, rejection mediated by the innate immune system, and chronic rejection. We present mechanisms of graft acceptance, including accommodation, regulation, and tolerance. Studies in animals have replicated many pathologic features of acute and chronic rejection. We illuminate the pathogenesis of human pathology by reflection from experimental models.

Original languageEnglish (US)
Title of host publicationAnnual Review of Pathology
Subtitle of host publicationMechanisms of Disease
EditorsAbul Abbas, Stephen Galli, Peter Howley
Number of pages32
StatePublished - 2008

Publication series

NameAnnual Review of Pathology: Mechanisms of Disease
ISSN (Print)1553-4006
ISSN (Electronic)1553-4014


  • Accommodation
  • Acute rejection
  • Antibody
  • Chronic rejection
  • Renal allograft

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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