Ketamine: Stimulating antidepressant treatment?

Gin S. Malhi, Yulisha Byrow, Frederick Cassidy, Andrea Cipriani, Koen Demyttenaere, Mark A. Frye, Michael Gitlin, Sidney H. Kennedy, Terence A. Ketter, Raymond W. Lam, Rupert McShane, Alex J. Mitchell, Michael J. Ostacher, Sakina J. Rizvi, Michael E. Thase, Mauricio Tohen

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


The appeal of ketamine - in promptly ameliorating depressive symptoms even in those with non-response - has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ketamine's potential as an option for treating depression and provide a synthesis of perspectives - derived from evidence and clinical experience - and to consider strategies for future investigations.

Original languageEnglish (US)
Pages (from-to)E5-E9
JournalBJPsych Open
Issue number3
StatePublished - 2016

ASJC Scopus subject areas

  • Psychiatry and Mental health


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