Isolation, Labeling, and Characterization of Cells in a Microfluidic Microwell Device for Cell Therapy Manufacturing

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cell therapy is an emerging field of medical treatment that uses living cells to treat a broad array of acute and chronic diseases. Early results from cell therapy trials have demonstrated efficacy with a generally safe profile. Most of these trials have used standard methods for culture, isolation and analysis. As these technologies evolve, new methods are needed to scale manufacturing while maintaining process integrity, reducing environmental exposure, and limiting critical cell and reagent use. Here, we show initial results towards this goal on a microfluidic device integrating cell separation and on-chip labeling with no cell loss.

Original languageEnglish (US)
Title of host publicationMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages817-818
Number of pages2
ISBN (Electronic)9781733419031
StatePublished - 2021
Event25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, United States
Duration: Oct 10 2021Oct 14 2021

Publication series

NameMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Country/TerritoryUnited States
CityPalm Springs, Virtual
Period10/10/2110/14/21

Keywords

  • cell therapy
  • dendritic cells
  • immunomagnetic separation
  • label
  • microwells
  • wash

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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