TY - JOUR
T1 - Is early life exposure to polyomaviruses and herpesviruses associated with obesity indices and metabolic traits in childhood?
AU - Karachaliou, Marianna
AU - de Sanjose, Silvia
AU - Waterboer, Tim
AU - Roumeliotaki, Theano
AU - Vassilaki, Maria
AU - Sarri, Katerina
AU - Leventakou, Vasiliki
AU - Vafeiadi, Marina
AU - Chalkiadaki, Georgia
AU - Stiakaki, Eftichia
AU - Michel, Angelika
AU - Pawlita, Michael
AU - Kogevinas, Manolis
AU - Chatzi, Leda
N1 - Publisher Copyright:
© 2018, Macmillan Publishers Limited, part of Springer Nature.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Background: Evidence for an infectious origin of obesity is emerging. We explored whether common viruses were associated with obesity and metabolic traits. Methods: We used cross-sectional (n = 674) and prospective (n = 440) data from children participating at the 4 and 6 years of age follow-up in the Rhea birth cohort. Presence of IgG antibodies to ten polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses (EBV, CMV, HSV-1, and HSV-2) were measured at age 4. Body mass index, waist circumference, and skinfold thickness were measured at age 4 and 6. Data on serum lipids, leptin, and adiponectin were also available. Multivariable linear regression models were used to explore the associations. Results: At 4 years of age, seroprevalence to polyomaviruses ranged from 21.0% for HPyV9 to 82.0% for HPyV10. Seroprevalence for EBV, CMV, HSV-1, and HSV-2 was 53.0%, 26.0%, 3.6%, and 1.5% respectively. BKPyV seropositivity was associated with lower BMI SD score at age 4 [−0.21 (95% CI: −0.39, −0.03)] and 6 [−0.27 (95% CI:-0.48, −0.05)], waist circumference at age 4 [−1.12 cm (95% CI: −2.10, −0.15)] and 6 [−1.73 cm (95% CI: −3.33, −0.12)], sum of four skinfolds [−2.97 mm (95% CI: −5.70, −0.24)], and leptin levels at age 4 [ratio of geometric means, 0.83 (95% CI: 0.70, 0.98)]. CMV seropositivity was associated with higher BMI SD score at age 4 [0.28 (95% CI: 0.11, 0.45)] and 6 [0.24 (95% CI: 0.03, 0.45)] and sum of four skinfolds at age 6 [4.75 mm (95% CI: 0.67, 8.83)]. Having “2–3 herpesviruses infections” (versus “0 herpesvirus infections”) was associated with higher BMI SD score [0.32, (95% CI: 0.12, 0.53)], waist circumference [1.22 cm (95% CI: 0.13, 2.31)], and sum of four skinfolds [3.26 mm (95% CI: 0.18, 6.35)] at age 4. Polyomaviruses burden was not associated with outcomes. Conclusions: A higher herpesviruses burden and CMV seropositivity were associated with obesity traits in childhood.
AB - Background: Evidence for an infectious origin of obesity is emerging. We explored whether common viruses were associated with obesity and metabolic traits. Methods: We used cross-sectional (n = 674) and prospective (n = 440) data from children participating at the 4 and 6 years of age follow-up in the Rhea birth cohort. Presence of IgG antibodies to ten polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses (EBV, CMV, HSV-1, and HSV-2) were measured at age 4. Body mass index, waist circumference, and skinfold thickness were measured at age 4 and 6. Data on serum lipids, leptin, and adiponectin were also available. Multivariable linear regression models were used to explore the associations. Results: At 4 years of age, seroprevalence to polyomaviruses ranged from 21.0% for HPyV9 to 82.0% for HPyV10. Seroprevalence for EBV, CMV, HSV-1, and HSV-2 was 53.0%, 26.0%, 3.6%, and 1.5% respectively. BKPyV seropositivity was associated with lower BMI SD score at age 4 [−0.21 (95% CI: −0.39, −0.03)] and 6 [−0.27 (95% CI:-0.48, −0.05)], waist circumference at age 4 [−1.12 cm (95% CI: −2.10, −0.15)] and 6 [−1.73 cm (95% CI: −3.33, −0.12)], sum of four skinfolds [−2.97 mm (95% CI: −5.70, −0.24)], and leptin levels at age 4 [ratio of geometric means, 0.83 (95% CI: 0.70, 0.98)]. CMV seropositivity was associated with higher BMI SD score at age 4 [0.28 (95% CI: 0.11, 0.45)] and 6 [0.24 (95% CI: 0.03, 0.45)] and sum of four skinfolds at age 6 [4.75 mm (95% CI: 0.67, 8.83)]. Having “2–3 herpesviruses infections” (versus “0 herpesvirus infections”) was associated with higher BMI SD score [0.32, (95% CI: 0.12, 0.53)], waist circumference [1.22 cm (95% CI: 0.13, 2.31)], and sum of four skinfolds [3.26 mm (95% CI: 0.18, 6.35)] at age 4. Polyomaviruses burden was not associated with outcomes. Conclusions: A higher herpesviruses burden and CMV seropositivity were associated with obesity traits in childhood.
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U2 - 10.1038/s41366-018-0017-1
DO - 10.1038/s41366-018-0017-1
M3 - Article
C2 - 29445241
AN - SCOPUS:85042132621
SN - 0307-0565
VL - 42
SP - 1590
EP - 1601
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 9
ER -