TY - JOUR
T1 - Irreversible electroporation
T2 - Evolution of a laboratory technique in interventional oncology
AU - Deipolyi, Amy R.
AU - Golberg, Alexander
AU - Yarmush, Martin L.
AU - Arellano, Ronald S.
AU - Oklu, Rahmi
PY - 2014
Y1 - 2014
N2 - Electroporation involves applying electric field pulses to cells, leading to the alteration or destruction of cell membranes. Irreversible electroporation (IRE) creates permanent defects in cell membranes and induces cell death. By directly targeting IRE to tumors, percutaneous nonthermal ablation is possible. The history of IRE, evolution of concepts, theory, biological applications, and clinical data regarding its safety and efficacy are discussed.
AB - Electroporation involves applying electric field pulses to cells, leading to the alteration or destruction of cell membranes. Irreversible electroporation (IRE) creates permanent defects in cell membranes and induces cell death. By directly targeting IRE to tumors, percutaneous nonthermal ablation is possible. The history of IRE, evolution of concepts, theory, biological applications, and clinical data regarding its safety and efficacy are discussed.
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U2 - 10.5152/dir.2013.13304
DO - 10.5152/dir.2013.13304
M3 - Review article
C2 - 24412820
AN - SCOPUS:84895488256
SN - 1305-3825
VL - 20
SP - 147
EP - 154
JO - Diagnostic and Interventional Radiology
JF - Diagnostic and Interventional Radiology
IS - 2
ER -