Iron-laden blasts in refractory acute myeloid leukemia

Christopher Vossen; Roeun Im; Pedro Horna

doi:10.1007/s12308-023-00555-6

Iron-laden blasts in refractory acute myeloid leukemia

Christopher Vossen, Roeun Im, Pedro Horna

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of refractory acute myeloid leukemia with DEK-NUP214 rearrangement showing circulating monocytic blasts with abundant green cytoplasmic granules on the Wright-Giemsa stain. The granules were strongly positive for Perls’ Prussian blue, consistent with hemosiderin deposits. This previously unreported finding is suggestive of siderophage activity by leukemic blasts, likely associated with monocytic differentiation.

Original language	English (US)
Pages (from-to)	187-188
Number of pages	2
Journal	Journal of Hematopathology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1007/s12308-023-00555-6
State	Published - Sep 2023

Keywords

Acute myeloid leukemia
Green cytoplasmic granules
Hemosiderin-laden blasts

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Hematology

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10.1007/s12308-023-00555-6

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title = "Iron-laden blasts in refractory acute myeloid leukemia",

abstract = "We report a case of refractory acute myeloid leukemia with DEK-NUP214 rearrangement showing circulating monocytic blasts with abundant green cytoplasmic granules on the Wright-Giemsa stain. The granules were strongly positive for Perls{\textquoteright} Prussian blue, consistent with hemosiderin deposits. This previously unreported finding is suggestive of siderophage activity by leukemic blasts, likely associated with monocytic differentiation.",

keywords = "Acute myeloid leukemia, Green cytoplasmic granules, Hemosiderin-laden blasts",

author = "Christopher Vossen and Roeun Im and Pedro Horna",

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language = "English (US)",

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AU - Vossen, Christopher

AU - Im, Roeun

AU - Horna, Pedro

PY - 2023/9

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N2 - We report a case of refractory acute myeloid leukemia with DEK-NUP214 rearrangement showing circulating monocytic blasts with abundant green cytoplasmic granules on the Wright-Giemsa stain. The granules were strongly positive for Perls’ Prussian blue, consistent with hemosiderin deposits. This previously unreported finding is suggestive of siderophage activity by leukemic blasts, likely associated with monocytic differentiation.

AB - We report a case of refractory acute myeloid leukemia with DEK-NUP214 rearrangement showing circulating monocytic blasts with abundant green cytoplasmic granules on the Wright-Giemsa stain. The granules were strongly positive for Perls’ Prussian blue, consistent with hemosiderin deposits. This previously unreported finding is suggestive of siderophage activity by leukemic blasts, likely associated with monocytic differentiation.

KW - Acute myeloid leukemia

KW - Green cytoplasmic granules

KW - Hemosiderin-laden blasts

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IS - 3

ER -

Iron-laden blasts in refractory acute myeloid leukemia

Abstract

Keywords

ASJC Scopus subject areas

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