Involvement of Medullary Serotonergic Groups in Multiple System Atrophy

Eduardo E. Benarroch, Ann M. Schmeichel, Phillip A. Low, Joseph E. Parisi

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


We sought to determine whether medullary serotonergic neurons were affected in multiple system atrophy (MSA). Immunostaining for tryptophan hydroxylase was performed on serial 50μm sections of the medulla of brains obtained at autopsy from six control subjects, eight subjects with clinical diagnosis of MSA, and four with Parkinson's disease. There was a severe depletion of serotonergic neurons in the nucleus raphe magnus, raphe obscurus, raphe pallidus, and ventrolateral medulla in MSA. Depletion of serotonergic neurons may contribute to impaired control of sympathetic outflow and other abnormalities in MSA.

Original languageEnglish (US)
Pages (from-to)418-422
Number of pages5
JournalAnnals of neurology
Issue number3
StatePublished - Mar 2004

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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