Invited review: Plasma membrane stress failure in alveolar epithelial cells

Nicholas E. Vlahakis, Rolf D. Hubmayr

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations


In this review, we examine the hypothesis that plasma membrane stress failure is a central event in the pathophysiology of injury from alveolar overdistension. This hypothesis leads us to consider alveolar micromechanics and specifically the mechanical interactions between lung matrix and alveolar epithelial cell cytoskeleton and plasma membrane. We then explore events that are central to the regulation of plasma membrane tension and detail the lipid-trafficking responses of in vitro deformed and/or injured cells. We conclude with a reference to upregulation of stress-responsive genes after membrane injury and resealing.

Original languageEnglish (US)
Pages (from-to)2490-2496
Number of pages7
JournalJournal of applied physiology
Issue number6
StatePublished - 2000


  • Cell deformation
  • Lipid trafficking
  • Lung injury
  • Mechanical stress

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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