TY - JOUR
T1 - Invited editorial presents an accurate summary of the results of two randomised placebo-controlled trials of vertebroplasty
AU - Buchbinder, Rachelle
AU - Osborne, Richard H.
AU - Kallmes, David
PY - 2010/3/15
Y1 - 2010/3/15
N2 - • Our recent editorial in the Journal presents an accurate summary of our two randomised trials of vertebroplasty, which found no benefit of vertebroplasty over placebo. • Participants in both trials are representative of patients seen in clinical practice and who would qualify for government-subsidised funding of vertebroplasty in Australia. • Clinical experience and previous published literature are likely to have overestimated the treatment benefit of vertebroplasty for many reasons. • This is why randomised placebo-controlled trials are required to determine the efficacy of treatment interventions, particularly when the condition being treated is self-limiting and the primary end point is improvement of symptoms. • Based on the best evidence currently available, the routine use of vertebroplasty outside of the research setting for painful osteoporotic vertebral fractures appears unjustified.
AB - • Our recent editorial in the Journal presents an accurate summary of our two randomised trials of vertebroplasty, which found no benefit of vertebroplasty over placebo. • Participants in both trials are representative of patients seen in clinical practice and who would qualify for government-subsidised funding of vertebroplasty in Australia. • Clinical experience and previous published literature are likely to have overestimated the treatment benefit of vertebroplasty for many reasons. • This is why randomised placebo-controlled trials are required to determine the efficacy of treatment interventions, particularly when the condition being treated is self-limiting and the primary end point is improvement of symptoms. • Based on the best evidence currently available, the routine use of vertebroplasty outside of the research setting for painful osteoporotic vertebral fractures appears unjustified.
UR - http://www.scopus.com/inward/record.url?scp=77952396461&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952396461&partnerID=8YFLogxK
U2 - 10.5694/j.1326-5377.2010.tb03534.x
DO - 10.5694/j.1326-5377.2010.tb03534.x
M3 - Review article
C2 - 20230352
AN - SCOPUS:77952396461
SN - 0025-729X
VL - 192
SP - 338
EP - 341
JO - Medical Journal of Australia
JF - Medical Journal of Australia
IS - 6
ER -