@article{b0a8fdc6af074dd28fb58e31aba0b0c3,
title = "Invasive Electrophysiology for Circuit Discovery and Study of Comorbid Psychiatric Disorders in Patients With Epilepsy: Challenges, Opportunities, and Novel Technologies",
abstract = "Intracranial electroencephalographic (iEEG) recordings from patients with epilepsy provide distinct opportunities and novel data for the study of co-occurring psychiatric disorders. Comorbid psychiatric disorders are very common in drug-resistant epilepsy and their added complexity warrants careful consideration. In this review, we first discuss psychiatric comorbidities and symptoms in patients with epilepsy. We describe how epilepsy can potentially impact patient presentation and how these factors can be addressed in the experimental designs of studies focused on the electrophysiologic correlates of mood. Second, we review emerging technologies to integrate long-term iEEG recording with dense behavioral tracking in naturalistic environments. Third, we explore questions on how best to address the intersection between epilepsy and psychiatric comorbidities. Advances in ambulatory iEEG and long-term behavioral monitoring technologies will be instrumental in studying the intersection of seizures, epilepsy, psychiatric comorbidities, and their underlying circuitry.",
keywords = "SEEG (stereoelectroencephalography), biomarker, deep brain stimulation, electrocorticography (ECoG), epilepsy, major depression (MDD), neuromodulation, psychiatric disorders",
author = "Irena Balzekas and Vladimir Sladky and Petr Nejedly and Brinkmann, {Benjamin H.} and Daniel Crepeau and Filip Mivalt and Gregg, {Nicholas M.} and {Pal Attia}, Tal and Marks, {Victoria S.} and Lydia Wheeler and Riccelli, {Tori E.} and Staab, {Jeffrey P.} and Lundstrom, {Brian Nils} and Miller, {Kai J.} and {Van Gompel}, Jamie and Vaclav Kremen and Croarkin, {Paul E.} and Worrell, {Gregory A.}",
note = "Funding Information: Special thanks to our patients. We would like to thank Karla Crockett and Cindy Nelson for making this research a reality through their administrative, logistical, and patient-driven contributions. Medtronic provided Summit RC+STM systems and technical support. We appreciate the support and scientific collaboration with colleagues at Medtronic, and in particular Abbey Becker, PhD, Dave Linde, and Rob Raike, PhD. Funding. This work was supported by funding from NIH Brain Initiative UH2&3 NS095495. PC was supported by the National Institute of Mental Health under Award Numbers R01MH113700 and R01MH124655. BB was supported by the Epilepsy Foundation of America{\textquoteright}s Epilepsy Innovation Institute My Seizure Gauge award. KM was funded by Brain and Behavior Research Foundation with a NARSAD Young Investigator Grant, NIH-NCATS CTSA KL2 TR002379, and the Foundation for OCD Research. VK was partially supported by institutional funding of Czech Technical University in Prague, Prague, Czechia. IB was supported by the National Institute of General Medical Sciences (T32 GM 65841). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Health. Funding Information: This work was supported by funding from NIH Brain Initiative UH2&3 NS095495. PC was supported by the National Institute of Mental Health under Award Numbers R01MH113700 and R01MH124655. BB was supported by the Epilepsy Foundation of America{\textquoteright}s Epilepsy Innovation Institute My Seizure Gauge award. KM was funded by Brain and Behavior Research Foundation with a NARSAD Young Investigator Grant, NIH-NCATS CTSA KL2 TR002379, and the Foundation for OCD Research. VK was partially supported by institutional funding of Czech Technical University in Prague, Prague, Czechia. IB was supported by the National Institute of General Medical Sciences (T32 GM 65841). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Health. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Balzekas, Sladky, Nejedly, Brinkmann, Crepeau, Mivalt, Gregg, Pal Attia, Marks, Wheeler, Riccelli, Staab, Lundstrom, Miller, Van Gompel, Kremen, Croarkin and Worrell.",
year = "2021",
month = jul,
day = "26",
doi = "10.3389/fnhum.2021.702605",
language = "English (US)",
volume = "15",
journal = "Frontiers in Human Neuroscience",
issn = "1662-5161",
publisher = "Frontiers Research Foundation",
}