Intraventricular perineurioma: Case report

Caterina Giannini, Bernd W. Scheithauer, Joel Steinberg, Theodore J. Cosgrove

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


OBJECTIVE AND IMPORTANCE: Perineurioma, a rare benign nerve sheath neoplasm occurring in either an intraneural or soft tissue form, has never been reported to arise in the central nervous system. CLINICAL PRESENTATION: We describe the clinical, radiological, and pathological features of a perineurioma arising in the choroid plexus of the third ventricle in a 65- year-old woman and causing obstructive hydrocephalus. INTERVENTION: The lesion, apparently unassociated with a nerve, was gross totally resected by frontal craniotomy using a left-sided transcallosal approach. Short-term follow-up showed no evidence of recurrence. CONCLUSION: Perineurioma of the variety found in soft tissue may occur in the central nervous system, wherein it shows the typical light microscopic, immunohistochemical (epithelial membrane antigen- and Collagen IV-positive, S-100 protein-negative), and ultrastructural (pinocytotic vesicles, discontinuous basement membrane) features.

Original languageEnglish (US)
Pages (from-to)1478-1482
Number of pages5
Issue number6
StatePublished - Dec 1998


  • Brain
  • Choroid plexus
  • Differential diagnosis
  • Immunohistochemistry
  • Nerve sheath tumor
  • Perineurioma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Intraventricular perineurioma: Case report'. Together they form a unique fingerprint.

Cite this