Intravascular lymphomatosis presenting in the lung

Samuel A. Yousem, Thomas V. Colby

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


We report four patients who had intravascular lymphomatosis (IVL) that presented as interstitial lung disease. All four patients had progressive shortness of breath, weight loss, fever, and diffuse interstitial infiltrates on chest radiographs. Open lung biopsy samples showed an interstitial pneumonia except for the intravascular proliferation of large lymphoid cells associated with irregular congestion, fibrin microthrombi, and intimal proliferation in vessels. This appearance corresponded to an intravascular large cell lymphoma (malignant angioendotheliomatosis [MAE], angiotropic lymphoma). The differential diagnosis of IVL with other pulmonary lymphoproliferations and intravascular malignancies is reported.

Original languageEnglish (US)
Pages (from-to)349-353
Number of pages5
Issue number2
StatePublished - Jan 15 1990

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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