Abstract
Responsive neurostimulation (RNS) and deep brain stimulation (DBS) of the anterior nucleus of the thalamus are two types of intracranial electrical stimulation used for the treatment of focal seizures in patients with drug-resistant epilepsies. RNS refers intracranial stimulation provided by a skull-based computerized device that provides electrical stimulation in response to ongoing sources of brain activity potentially reflecting seizures. DBS provides continuous or cyclic electrical stimulation to the targeted areas of the thalamus. Candidates for intracranial electrical stimulation include patients with drug-resistant focal epilepsy who are not suitable candidates for epilepsy surgery or ablative therapy. Both RNS and DBS reduce seizure frequency by about half after 1 year. As with all types of devices that deliver neurostimulation, neuromodulation reflects the benefits of stimulation on seizure reduction that improves over time suspected to result from network reorganization.
| Original language | English (US) |
|---|---|
| Title of host publication | Epilepsy Case Studies |
| Subtitle of host publication | Pearls for Patient Care: Second Edition |
| Publisher | Springer International Publishing |
| Pages | 265-269 |
| Number of pages | 5 |
| ISBN (Electronic) | 9783030590789 |
| ISBN (Print) | 9783030590772 |
| DOIs | |
| State | Published - Dec 19 2020 |
Keywords
- Deep brain stimulation
- Drug resistant
- Focal epilepsy
- Responsive neurostimulation
- Seizures
- Sudden unexpected death in epilepsy
ASJC Scopus subject areas
- General Medicine