Intracellular Signaling Pathways Mediating Tyrosine Kinase Inhibitor Cardiotoxicity

Shane S. Scott, Ashley N. Greenlee, Anna Matzko, Matthew Stein, Michael T. Naughton, Taborah Z. Zaramo, Ethan J. Schwendeman, Somayya J. Mohammad, Mamadou Diallo, Rohith Revan, Gabriel Shimmin, Shwetabh Tarun, Joel Ferrall, Thai H. Ho, Sakima A. Smith

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish (US)
Pages (from-to)425-442
Number of pages18
JournalHeart Failure Clinics
Issue number3
StatePublished - Jul 2022


  • Arrhythmias
  • Cardio-oncology
  • Cardiotoxicity
  • Hypertension 5’ AMP-activated protein kinase (AMPK)
  • Intracellular signaling
  • Phosphoinositide 3-kinase (PI3K) signaling
  • Tyrosine kinase inhibitors (TKIs)
  • Vascular endothelial growth factor receptor (VEGFR)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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