Intestinal barrier function in health and gastrointestinal disease

M. Camilleri, K. Madsen, R. Spiller, B. G. Van Meerveld, G. N. Verne

Research output: Contribution to journalReview articlepeer-review

322 Scopus citations


Defects in intestinal barrier function are associated with diseases of the gastrointestinal (GI) tract. There is growing evidence that increases in intestinal permeability plays a pathogenic role in diseases, such as inflammatory bowel disease (IBD) and celiac disease, and functional bowel disorders, such as irritable bowel syndrome (IBS). This review takes a unique translational approach to discuss the physiological and pathophysiological mechanisms involved in the regulation of intestinal barrier function in IBS. The review summarizes the components of the intestinal barrier including the tight junction complex within the epithelium, and the methods used to assess gut permeability both in vitro and in vivo. Throughout the review, the authors have attempted to critically review the latest research from both experimental animal models and human studies to appraise whether intestinal barrier dysfunction is a primary cause of functional GI disorders, such as IBS....

Original languageEnglish (US)
Pages (from-to)503-512
Number of pages10
JournalNeurogastroenterology and Motility
Issue number6
StatePublished - Jun 2012


  • Glutamine
  • Intestinal barrier
  • Irritable bowel syndrome
  • MicroRNA
  • Tight junction proteins

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology


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