TY - JOUR
T1 - Intestinal Barrier Dysfunction in Inflammatory Bowel Disease
T2 - Underpinning Pathogenesis and Therapeutics
AU - Dunleavy, Katie A.
AU - Raffals, Laura E.
AU - Camilleri, Michael
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/12
Y1 - 2023/12
N2 - The intestinal barrier is composed of several essential elements including luminal enzymes, bile acids, water layer, epithelial layer, and enterocyte layer. It acts as a dynamic interface between the luminal contents of food, commensal and pathogenic bacteria, and the gastrointestinal tract. The role of barrier dysfunction is of significant research interest in the development and targeted treatment of chronic inflammatory gastrointestinal conditions, such as inflammatory bowel disease. This review aims to examine the role of intestinal barrier dysfunction in the development of inflammatory bowel disease, the pathophysiology of increased barrier permeability in inflammatory bowel disease, and to explore potential treatment targets and clinical applications.
AB - The intestinal barrier is composed of several essential elements including luminal enzymes, bile acids, water layer, epithelial layer, and enterocyte layer. It acts as a dynamic interface between the luminal contents of food, commensal and pathogenic bacteria, and the gastrointestinal tract. The role of barrier dysfunction is of significant research interest in the development and targeted treatment of chronic inflammatory gastrointestinal conditions, such as inflammatory bowel disease. This review aims to examine the role of intestinal barrier dysfunction in the development of inflammatory bowel disease, the pathophysiology of increased barrier permeability in inflammatory bowel disease, and to explore potential treatment targets and clinical applications.
KW - Inflammatory bowel disease
KW - Intestinal permeability
KW - Mucus
KW - Tight junctions
UR - http://www.scopus.com/inward/record.url?scp=85173035515&partnerID=8YFLogxK
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U2 - 10.1007/s10620-023-08122-w
DO - 10.1007/s10620-023-08122-w
M3 - Review article
C2 - 37773554
AN - SCOPUS:85173035515
SN - 0163-2116
VL - 68
SP - 4306
EP - 4320
JO - Digestive diseases and sciences
JF - Digestive diseases and sciences
IS - 12
ER -