Interventional resealing of preterm premature rupture of the membranes: a systematic review and meta-analysis

Eniola R. Ibirogba, Sherif A. Shazly, Kavita Narang, Waseem Wahood, Ayssa Teles Abrao Trad, Michael E. Tsimis, Rodrigo Ruano

Research output: Contribution to journalReview articlepeer-review


Objective: To compare the effectiveness and outcomes of interventional resealing of membranes, “amniopatch” for spontaneous vs. iatrogenic preterm premature rupture of the membranes (sPPROM and iPPROM). Methods: We performed a systematic review of literature involving an electronic search of the following databases: Ovid MEDLINE(R) and Epub Ahead of Print, In-Process and Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, and Scopus. An indirect meta-analysis was then performed to compare the obstetric, maternal, fetal, and neonatal outcomes of amniopatch between the sPPROM and iPPROM groups. Results: The mean gestational age (GA) at the time rupture was 17.8 ± 1.8 and 25.2 ± 3.8 weeks for iPPROM and sPPROM, respectively, p =.005. Mean GA at the time of amniopatch procedure was 19.2 ± 2.07 weeks for iPPROM and 23 ± 3.1 weeks of gestation for sPPROM, p =.023. The rates of fluid re-accumulation (sPPROM 26% and iPPROM 53%, p =.09) were comparable between the sPPROM and iPPROM groups. Neonatal outcomes except for the rate of IUFD were also comparable between the groups. The incidence of IUFD was significantly higher in the iPPROM group (ES: 24%; 95% CI: 8.00–44.0%; p <.001), compared to sPPROM (ES: 0%; 95% CI: 0.00–4.00%). Obstetric and maternal outcomes were comparable between the two groups. Conclusions: Amniopatch appears to be a feasible and safe procedure for PPROM treatment. Further research is warranted to investigate the effectiveness of this procedure and establish a standardized criterion for the appropriate selection of patients that could benefit from this intervention.

Original languageEnglish (US)
Pages (from-to)5978-5992
Number of pages15
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number25
StatePublished - 2022


  • Fetal therapy
  • amniopatch
  • congenital anomalies
  • prenatal diagnosis
  • preterm premature rupture of the membranes
  • ultrasound

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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