Interrelationships of transcriptional machinery with nuclear architecture

Gary S. Stein, André J. Van Wijnen, Janet L. Stein, Jane B. Lian

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


There is increasing evidence for functional linkages between nuclear architecture and the regulation of gene expression. The nuclear matrix provides a paradigm for involvement of nuclear morphology in assembly of the biochemical machinery for physiological control of transcription. Mechanisms are being experimentally defined that direct regulatory factors to subnuclear sites that support gene expression. Consequently, we are gaining insight into the rules that govern transcriptional control within the three-dimensional context of nuclear organization.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalCritical Reviews in Eukaryotic Gene Expression
Issue number3-4
StatePublished - 1999


  • Chromatin
  • Gene expression
  • Intranuclear trafficking
  • Nuclear matrix

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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