Interleukin 4 promotes expression of mast cell ICAM-1 antigen

P. Valent, D. Bevec, D. Maurer, J. Besemer, F. Di Padova, J. H. Butterfield, W. Speiser, O. Majdic, K. Lechner, P. Bettelheim

Research output: Contribution to journalArticlepeer-review

96 Scopus citations


Cell recognition molecules play a crucial role in the regulation of immune cells. We recently found that mast cells (MCs) express leukocyte recognition molecules, including ICAM-1 antigen, a natural ligand of LFA-1. We here report that interleukin 4 (IL-4), a pleiotropic cytokine and mast cell differentiation factor, selectively promotes expression of surface ICAM-1 antigen and ICAM-1 mRNA in human MCs. IL-4 also up-regulates ICAM-1 antigen in cells of monocyte/macrophage lineage but has no effect on ICAM-1 antigen expressed on basophils, fibroblasts, or lymphocytes. The increase in expression of mast cell/macrophage ICAM-1 antigen induced by IL-4 may contribute to the accumulation of leukocytes and facilitate cell-contact-dependent regulation of immune cells in inflammed tissues.

Original languageEnglish (US)
Pages (from-to)3339-3342
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number8
StatePublished - 1991


  • Cytokines
  • Mast cells
  • Recognition molecules

ASJC Scopus subject areas

  • General


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