Abstract
Over the past few years, association studies have proposed a number of potential genetic risk factors for Alzheimer's disease (AD). With the exception of the ε4 allele of the apolipoprotein E gene, whose association with the late onset type of AD (LOAD) has been confirmed, the relative significance of most of these associations is still in question. A polymorphism in the interleukin-1A gene (IL-1A2) has been suggested as a risk factor for the early onset as well as for LOAD. In this study, the distribution of IL-1A alleles was examined in a cohort of predominantly LOAD patients and in control individuals. No significant difference was detected in genotype or allele frequencies (odds ratios of 0.929 and 0.743, respectively; P>0.5). We conclude that IL-1A genotype is not a major risk factor for LOAD.
Original language | English (US) |
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Pages (from-to) | 81-83 |
Number of pages | 3 |
Journal | Neuroscience Letters |
Volume | 323 |
Issue number | 1 |
DOIs | |
State | Published - Apr 19 2002 |
Keywords
- Alzheimer's disease
- Genetics
- Interleukin-1A
- Polymorphism
ASJC Scopus subject areas
- General Neuroscience