Interferon-γ 3 induces progressive nigrostriatal degeneration and basal ganglia calcification

Paramita Chakrabarty; Carolina Ceballos-Diaz; Wen Lang Lin; Amanda Beccard; Karen Jansen-West; Nikolaus R. McFarland; Christopher Janus; Dennis Dickson; Pritam Das; Todd E. Golde

doi:10.1038/nn.2829

Interferon-γ 3 induces progressive nigrostriatal degeneration and basal ganglia calcification

Paramita Chakrabarty, Carolina Ceballos-Diaz, Wen Lang Lin, Amanda Beccard, Karen Jansen-West, Nikolaus R. McFarland, Christopher Janus, Dennis Dickson, Pritam Das, Todd E. Golde

Neuroscience

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

We found that CNS-directed expression of interferon-γ 3 (IFN-γ 3) resulted in basal ganglia calcification, reminiscent of human idiopathic basal ganglia calcification (IBGC), and nigrostriatal degeneration. Our results indicate that IFN-γ 3 mediates age-progressive nigrostriatal degeneration in the absence of exogenous stressors. Further study of this model may provide insight into selective nigrostriatal degeneration in human IBGC and other Parkinson syndromes.

Original language	English (US)
Pages (from-to)	694-696
Number of pages	3
Journal	Nature Neuroscience
Volume	14
Issue number	6
DOIs	https://doi.org/10.1038/nn.2829
State	Published - Jun 2011

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Neuroscience(all)

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abstract = "We found that CNS-directed expression of interferon-γ 3 (IFN-γ 3) resulted in basal ganglia calcification, reminiscent of human idiopathic basal ganglia calcification (IBGC), and nigrostriatal degeneration. Our results indicate that IFN-γ 3 mediates age-progressive nigrostriatal degeneration in the absence of exogenous stressors. Further study of this model may provide insight into selective nigrostriatal degeneration in human IBGC and other Parkinson syndromes.",

author = "Paramita Chakrabarty and Carolina Ceballos-Diaz and Lin, {Wen Lang} and Amanda Beccard and Karen Jansen-West and McFarland, {Nikolaus R.} and Christopher Janus and Dennis Dickson and Pritam Das and Golde, {Todd E.}",

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AU - Chakrabarty, Paramita

AU - Ceballos-Diaz, Carolina

AU - Lin, Wen Lang

AU - Beccard, Amanda

AU - Jansen-West, Karen

AU - McFarland, Nikolaus R.

AU - Janus, Christopher

AU - Dickson, Dennis

AU - Das, Pritam

AU - Golde, Todd E.

PY - 2011/6

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N2 - We found that CNS-directed expression of interferon-γ 3 (IFN-γ 3) resulted in basal ganglia calcification, reminiscent of human idiopathic basal ganglia calcification (IBGC), and nigrostriatal degeneration. Our results indicate that IFN-γ 3 mediates age-progressive nigrostriatal degeneration in the absence of exogenous stressors. Further study of this model may provide insight into selective nigrostriatal degeneration in human IBGC and other Parkinson syndromes.

AB - We found that CNS-directed expression of interferon-γ 3 (IFN-γ 3) resulted in basal ganglia calcification, reminiscent of human idiopathic basal ganglia calcification (IBGC), and nigrostriatal degeneration. Our results indicate that IFN-γ 3 mediates age-progressive nigrostriatal degeneration in the absence of exogenous stressors. Further study of this model may provide insight into selective nigrostriatal degeneration in human IBGC and other Parkinson syndromes.

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Interferon-γ 3 induces progressive nigrostriatal degeneration and basal ganglia calcification

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