Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine

Sharon Frey, Ron Dagan, Yaffa Ashur, Xiao Q. Chen, Jose Ibarra, Herwig Kollaritsch, Mark H. Mazur, Gregory A. Poland, Keith Reisinger, Emmanuel Walter, Pierre Van Damme, Jean H. Braconier, Ingrid Uhnoo, Martin Wahl, Mark M. Blatter, Dennis Clements, David Greenberg, Robert M. Jacobson, S. Ragnar Norrby, Mina RoweDaniel Shouval, Sue S. Simmons, Jan Van Hattum, Solveig Wennerholm, Jacqueline O'Brien Gress, Ivan Chan, Barbara Kuter

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers > 1/4 1 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.

Original languageEnglish (US)
Pages (from-to)2018-2022
Number of pages5
JournalJournal of Infectious Diseases
Issue number6
StatePublished - 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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