Intercostal muscle blood flow is elevated in old rats during submaximal exercise

Joshua R. Smith; K. Sue Hageman; Craig A. Harms; David C. Poole; Timothy I. Musch

doi:10.1016/j.resp.2019.02.003

Intercostal muscle blood flow is elevated in old rats during submaximal exercise

Joshua R. Smith, K. Sue Hageman, Craig A. Harms, David C. Poole, Timothy I. Musch

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Respiratory muscle blood flows (BF) increase substantially during exercise in younger adult rats. As aging is associated with altered pulmonary function, we hypothesized that old rats will have greater intercostal muscle BF and vascular conductances (VC) than young rats during submaximal exercise. Methods: Mean arterial pressure and respiratory muscle BFs (via carotid artery catheter and radiolabeled microspheres, respectively) were measured at rest and during submaximal exercise in young (n = 9) and old (n = 7) Fischer 344 X Brown Norway rats. Results: At rest, diaphragm, intercostal, and transversus abdominis BFs and VCs were not different between groups (all, p > 0.10). During submaximal exercise, old compared to young rats had greater intercostal BF (40 ± 6 vs 25 ± 2 mL/min/100 g) and VC (0.30 ± 0.05 vs 0.18 ± 0.02 mL/min/mmHg/100 g) (both, p ≤ 0.01). Diaphragm and transversus abdominis BFs and VCs were not different between groups during exercise (all, p > 0.24). Conclusions: These data demonstrate that intercostal muscle BF and VC are increased in old compared to young rats during submaximal exercise.

Original language	English (US)
Pages (from-to)	26-30
Number of pages	5
Journal	Respiratory Physiology and Neurobiology
Volume	263
DOIs	https://doi.org/10.1016/j.resp.2019.02.003
State	Published - May 2019

Keywords

Aging
Diaphragm
Respiratory muscle
Transversus abdominis

ASJC Scopus subject areas

Neuroscience(all)
Physiology
Pulmonary and Respiratory Medicine

Access to Document

10.1016/j.resp.2019.02.003

Cite this

@article{b5925367c2a74c14a479f22729d95dd3,

title = "Intercostal muscle blood flow is elevated in old rats during submaximal exercise",

abstract = "Background: Respiratory muscle blood flows (BF) increase substantially during exercise in younger adult rats. As aging is associated with altered pulmonary function, we hypothesized that old rats will have greater intercostal muscle BF and vascular conductances (VC) than young rats during submaximal exercise. Methods: Mean arterial pressure and respiratory muscle BFs (via carotid artery catheter and radiolabeled microspheres, respectively) were measured at rest and during submaximal exercise in young (n = 9) and old (n = 7) Fischer 344 X Brown Norway rats. Results: At rest, diaphragm, intercostal, and transversus abdominis BFs and VCs were not different between groups (all, p > 0.10). During submaximal exercise, old compared to young rats had greater intercostal BF (40 ± 6 vs 25 ± 2 mL/min/100 g) and VC (0.30 ± 0.05 vs 0.18 ± 0.02 mL/min/mmHg/100 g) (both, p ≤ 0.01). Diaphragm and transversus abdominis BFs and VCs were not different between groups during exercise (all, p > 0.24). Conclusions: These data demonstrate that intercostal muscle BF and VC are increased in old compared to young rats during submaximal exercise.",

keywords = "Aging, Diaphragm, Respiratory muscle, Transversus abdominis",

author = "Smith, {Joshua R.} and {Sue Hageman}, K. and Harms, {Craig A.} and Poole, {David C.} and Musch, {Timothy I.}",

note = "Funding Information: This work was supported by the National Institutes of Health [ HL-2-108328 to DCP] and American Heart Association [Grant-in-Aid 10 GRANT 4350011 to DCP and 18POST3990251 to JRS]. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = may,

doi = "10.1016/j.resp.2019.02.003",

language = "English (US)",

volume = "263",

pages = "26--30",

journal = "Respiratory Physiology and Neurobiology",

issn = "1569-9048",

publisher = "Elsevier",

}

TY - JOUR

T1 - Intercostal muscle blood flow is elevated in old rats during submaximal exercise

AU - Smith, Joshua R.

AU - Sue Hageman, K.

AU - Harms, Craig A.

AU - Poole, David C.

AU - Musch, Timothy I.

N1 - Funding Information: This work was supported by the National Institutes of Health [ HL-2-108328 to DCP] and American Heart Association [Grant-in-Aid 10 GRANT 4350011 to DCP and 18POST3990251 to JRS]. Publisher Copyright: © 2019 Elsevier B.V.

PY - 2019/5

Y1 - 2019/5

N2 - Background: Respiratory muscle blood flows (BF) increase substantially during exercise in younger adult rats. As aging is associated with altered pulmonary function, we hypothesized that old rats will have greater intercostal muscle BF and vascular conductances (VC) than young rats during submaximal exercise. Methods: Mean arterial pressure and respiratory muscle BFs (via carotid artery catheter and radiolabeled microspheres, respectively) were measured at rest and during submaximal exercise in young (n = 9) and old (n = 7) Fischer 344 X Brown Norway rats. Results: At rest, diaphragm, intercostal, and transversus abdominis BFs and VCs were not different between groups (all, p > 0.10). During submaximal exercise, old compared to young rats had greater intercostal BF (40 ± 6 vs 25 ± 2 mL/min/100 g) and VC (0.30 ± 0.05 vs 0.18 ± 0.02 mL/min/mmHg/100 g) (both, p ≤ 0.01). Diaphragm and transversus abdominis BFs and VCs were not different between groups during exercise (all, p > 0.24). Conclusions: These data demonstrate that intercostal muscle BF and VC are increased in old compared to young rats during submaximal exercise.

AB - Background: Respiratory muscle blood flows (BF) increase substantially during exercise in younger adult rats. As aging is associated with altered pulmonary function, we hypothesized that old rats will have greater intercostal muscle BF and vascular conductances (VC) than young rats during submaximal exercise. Methods: Mean arterial pressure and respiratory muscle BFs (via carotid artery catheter and radiolabeled microspheres, respectively) were measured at rest and during submaximal exercise in young (n = 9) and old (n = 7) Fischer 344 X Brown Norway rats. Results: At rest, diaphragm, intercostal, and transversus abdominis BFs and VCs were not different between groups (all, p > 0.10). During submaximal exercise, old compared to young rats had greater intercostal BF (40 ± 6 vs 25 ± 2 mL/min/100 g) and VC (0.30 ± 0.05 vs 0.18 ± 0.02 mL/min/mmHg/100 g) (both, p ≤ 0.01). Diaphragm and transversus abdominis BFs and VCs were not different between groups during exercise (all, p > 0.24). Conclusions: These data demonstrate that intercostal muscle BF and VC are increased in old compared to young rats during submaximal exercise.

KW - Aging

KW - Diaphragm

KW - Respiratory muscle

KW - Transversus abdominis

UR - http://www.scopus.com/inward/record.url?scp=85062459595&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062459595&partnerID=8YFLogxK

U2 - 10.1016/j.resp.2019.02.003

DO - 10.1016/j.resp.2019.02.003

M3 - Article

C2 - 30825527

AN - SCOPUS:85062459595

SN - 1569-9048

VL - 263

SP - 26

EP - 30

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

ER -

Intercostal muscle blood flow is elevated in old rats during submaximal exercise

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this