Integrin β3 links therapy resistance and cancer stem cell properties

Nagarajan Kannan, Long V. Nguyen, Connie J. Eaves

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin α v β 3 expression in multiple types of solid tumour stem cells is now shown to control a pro-survival pathway that contributes to therapy resistance.

Original languageEnglish (US)
Pages (from-to)397-399
Number of pages3
JournalNature Cell Biology
Issue number5
StatePublished - 2014

ASJC Scopus subject areas

  • Cell Biology


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